The Hemp Connection:
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Chromium is a commonly used (or at least recommended) supplement in PCOS. What is it, why is it recommended, and should you be taking it?

Chromium is a metal, just like iron and copper. It's not really needed in large amounts to do its job, which in the body, is to help metabolize sugar and fats.

Some researchers have suggested that chromium supplementation in PCOS can help insulin function. There are two articles in the National Library of Medicine database looking specifically at the use of chromium supplementation in PCOS. One study, using a dose of 200 mcg per day, resulted in improved glucose tolerance but not fertility. The second study bumped the dose up to 1000 micrograms per day, resulting in a 38% better ability to remove glucose from the blood.

BEFORE YOU RUSH OUT AND BUY A YEAR'S SUPPLY…

There are more than a few articles in the very same database connecting chromium picolinate to DNA damage. The earliest one, for someone writing so much about infertility, really caught my eye, as it was entitled, "Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells." Another study reported that offspring of pregnant mice who were given chromium picolinate had an increased incidence of skeletal defects.

In the United States, dietary chromium recommendations have actually been LOWERED.

Because this is such a popular supplement recommendation and I'm sure at least some readers will question this, I've put all the references I found at the bottom of this post.

What I did notice was that over time, articles started to appear that countered this finding. I'm not sure if that means that earlier studies were wrong, if study design was manipulated to generate a different outcome, or if nutrition scientists are still trying to figure out how chromium works in the body.

What I know is, there were enough reports of potential toxicity to cause concern, and I do my best not to make recommendations that future research might force me to backpedal on. The entire model of PCOS intervention promoted by inCYST is about preventing oxidative stress and its associated damage. Chromium picolinate was referred to as an oxidative stress agent in more than one of the cited references, so to encourage readers to supplement with it seemed counterproductive.

WHAT TO DO?

First of all, understand what it is that chromium does. The clue lies in the fourth sentence of this post, in which I mentioned that chromium is needed to metabolize sugar and fats. If you're eating less sugar and fat, you need less chromium! So…perhaps one very important thing you can do is create less of a need for chromium by working to reduce your sugar and fat intake. We've talked a lot about strategies for reducing sugar cravings and binge eating, which could be two of your most important chromium-balance strategies.

Know your dietary sources. What you CAN do about the deficiency that previous dietary choices may have created, is to be savvy about what foods naturally contain trace amounts of chromium. These include brewer's yeast, whole grains, liver, bran cereals, potatoes, romaine lettuce, onions, and tomatoes.

Skip the refined foods Part of the reason we may have so much trouble getting chromium in the diet is our love of processed foods. It's especially problematic when we eat a food (such as bread) that is eventually going to require chromium to be metabolized, that has had the chromium processed right out of it.

It's kind of like if your car is running inefficiently. It's blowing through gasoline at a rapid rate. You can keep the car running by putting more and more gasoline in it, or you can get a tuneup to increase your fuel efficiency. Both will work, but one is more likely to cause long term problems.

Lucidi RS, Thyer AC, Easton CA, Holden AE, Schenken RS, Brzyski RG. Effect of chromium supplementation on insulin resistance and ovarian and menstrual cyclicity in women with polycystic ovary syndrome. Fertil Steril. 2005 Dec;84(6):1755-7.

Stearns DM, Wise JP Sr, Patierno SR, Wetterhahn KE. Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J. 1995 Dec;9(15):1643-8.

Stearns DM, Belbruno JJ, Wetterhahn KE. A prediction of chromium(III) accumulation in humans from chromium dietary supplements. FASEB J. 1995 Dec;9(15):1650-7. Review.

Bagchi D, Bagchi M, Balmoori J, Ye X, Stohs SJ. Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Eur J Epidemiol. 1998 Sep;14(6):621-6.

Kato I, Vogelman JH, Dilman V, Karkoszka J, Frenkel K, Durr NP, Orentreich N, Toniolo P. Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil. Chem Res Toxicol. 1999 Jun;12(6):483-7.

Speetjens JK, Collins RA, Vincent JB, Woski SA. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Mol Cell Biochem. 2001 Jun;222(1-2):149-58.

Bagchi D, Bagchi M, Stohs SJ. Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene. Mutat Res. 2002 Jan 15;513(1-2):135-42.

Vincent JB. The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent. Sports Med. 2003;33(3):213-30.

Bailey MM, Boohaker JG, Sawyer RD, Behling JE, Rasco JF, Jernigan JJ, Hood RD, Vincent JB. Exposure of pregnant mice to chromium picolinate results in skeletal defects in their offspring. Birth Defects Res B Dev Reprod Toxicol. 2006 Jun;77(3):244-9.

Stallings DM, Hepburn DD, Hannah M, Vincent JB, O'Donnell J. Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogaster. Mutat Res. 2006 Nov 7;610(1-2):101-13.
Kim M, Lim JH, Ahn CS, Park K, Kim GT, Kim WT, Pai HS. Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana. Plant Cell. 2006 Sep;18(9):2341-55.

Andersson MA, Petersson Grawé KV, Karlsson OM, Abramsson-Zetterberg LA, Hellman BE.
Evaluation of the potential genotoxicity of chromium picolinate in mammalian cells in vivo and in vitro. Food Chem Toxicol. 2007 Jul;45(7):1097-106.

Hininger I, Benaraba R, Osman M, Faure H, Marie Roussel A, Anderson RA. Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes. Free Radic Biol Med. 2007 Jun 15;42(12):1759-65.

Bailey MM, Sturdivant J, Jernigan PL, Townsend MB, Bushman J, Ankareddi I, Rasco JF, Hood RD, Vincent JB. Comparison of the potential for developmental toxicity of prenatal exposure to two dietary chromium supplements, chromium picolinate and [Cr3O(O2CCH2CH3)(6(H2O)3]+, in mice. Birth Defects Res B Dev Reprod Toxicol. 2008 Feb;83(1):27-31.
Komorowski JR, Greenberg D, Juturu V. Chromium picolinate does not produce chromosome damage. Toxicol In Vitro. 2008 Apr;22(3):819-26.

Komorowski JR, Greenberg D, Juturu V. Chromium picolinate does not produce chromosome damage. Toxicol In Vitro. 2008 Apr;22(3):819-26.

Tan GY, Zheng SS, Zhang MH, Feng JH, Xie P, Bi JM. Study of oxidative damage in growing-finishing pigs with continuous excess dietary chromium picolinate intake. Biol Trace Elem Res. 2008 Winter;126(1-3):129-40.

Tan GY, Bi JM, Zhang MH, Feng JH, Xie P, Zheng SS. Effects of chromium picolinate on oxidative damage in primary piglet hepatocytes. Biol Trace Elem Res. 2008 Dec;126 Suppl 1:S69-79.

I'm not surprised at the number of people who choose the"healthy" versions of things they know are normally not so healthy, based solely on an eye-catching blurb on the front of a package. Things like “trans-fat-free” flavored non-dairy creamer, or chocolate chip cookies “made with whole grains.” And are they really trans-fat-free or made with whole grains? Most of us won't even turn the package around to read the ingredients and find out what that means.

If there's a big graphic on the front with the words"0 grams trans fat per serving" most people will see that and think,"Perfect. I know trans fats are a bad thing, not sure what it is but I'm glad my favorite hazelnut flavored creamer doesn't have it!" And off they go. What they didn’t notice is that the second ingredient on the back was “partially hygrogenated oil” which is – you guessed it – trans fat. The serving size is a teaspoon. Can most of you who use flavored creamers honestly say that you take out a measuring teaspoon and put just that much into your coffee? If you’re like most people I know, you either pour some into your coffee until the color is right (definitely more than a teaspoon), or you use multiple single-serve packets wherever you get your coffee. The loophole is that if it’s less than 0.5g per serving, they can claim it’s got 0 trans fat. So the serving is tiny, not true to what most people actually use.

Same goes with other things like Goldfish crackers. Ooooh! It peeves me so! I was at Target doing some shopping and they have monster-sized bags of Goldfish crackers on sale. And not just any Goldfish crackers. The ones that are"made with whole grains". So here you are, trying to make small changes, since that is what you keep hearing is the easiest to do. A small change might be to find a healthier alternative to the little Goldfish you snack on mindlessly after work every evening. And holy crap! Here’s a “whole grain” version – that’s healthy! Right? Wrong.

Yes. the ingredient panel on the back lists"100% whole grain flour" as the first ingredient, but I took one down the aisle to where the regular Goldfish crackers were to compare. There really wasn't much of a difference – marginal at best. The “healthier” version has about 10 calories less per serving (1 serving is 55 Goldfish for both kinds). It also has 1 gram more of fiber per serving, so from 1 gram in the original, up to a whopping 2 grams in the healthier version. Though it has less fat, it has more saturated fat. And the “healthier” version also has more sodium. So really, is it any better, cumulatively? Not really, though I can hear Goldfish fanatics justifying that extra gram of fiber and 10 less calories to death. It’s still a highly-processed junky food, trying to weasel its way back into your home since chances are if you’re like many Americans, you’re trying to eat healthier.

Food labels are a tricky little business, and if you think the label is there to help you, the consumer, you’re in for a rude awakening. That's just what the food companies want you to believe. At the end of the day, everything they put on a label is carefully thought out, with their bottom line at the top of the priority list. International Delights and Pepperidge Farms (and soooo many others) don’t want to lose you as a customer so they figure, if you’re wising (wisening?) up about nutrition, they’ll play to your new level of nutrition knowledge and keep you around with misleading serving size loopholes and a trivial amount of whole grains in some of their junk products.

Here are some terms to keep in mind when you’re at the store:

• “Zero Grams Trans Fat Per Serving” – hydrogenated and partially-hydrogenated oils – of any kind – are trans fats. If these words appear on an ingredient list, feel free to call B.S. on the “zero grams” claim. Also look at your serving size and see if that is truly what you use.

  This goes for “Fat Free” as well. Remember if it’s less than 0.5 gram of fat per serving they can get away with saying it’s fat free. But if you use multiple times what the recommended serving size is, you’re gonna have to accept that it’s not truly fat-free – this is huge for people trying to lose weight, as the calories will add up faster than you think!

• “Made with Whole Grains” – First ask yourself is it really made with 100% whole grains? Then compare to the original and see if they’re BS-ing you with trivial differences that add up to nothing other than money in the bank for the company.
• “All Natural” – this is not a regulated claim, and any company can use this phrase and interpret their own meaning of what is “natural”. If you find ingredients on the nutrition panel that sure as heck don’t sound natural, well then…
• “No added sugar” – look for other sources of sugar that aren’t literally “sugar” like brown rice syrup, evaporated cane juice, fruit juice concentrate, and also keep an eye out for artificial sweeteners and sugar alcohols (aspartame, sucralose, sorbitol, maltitol, lactitol… etc.
• “Made with natural sugar” – Hey, that’s great. But you know what? Sugar is sugar, and too much of it, “natural” or otherwise is not going to add up to anything good in the long run. All your body knows when you put the food in your mouth is, “HEY!!!! Sugar!!! Now it’s a party!” Sugar in moderation won’t kill most people, but somehow, telling someone that it’s “natural” sugar or “raw” sugar, suddenly makes it ok to eat more. And that won’t necessarily save lives, either. Be smart about it.
• “Zero Calories / Calorie-Free” – Like with fats, if it has less than 5 calories per serving, the food company can get away with saying it has zero calories per serving. Rule of thumb is to consider all those zero-calorie items to have 4 calories. And as you might have heard, calories can add up rather quickly. Knowing that, if you’re drinking quite a bit of these zero-calorie beverages, or using multiple servings of zero-calorie salad dressing, you may be motivated to change your ways, if you’re actively counting calories (which I would hope would be the only reason you’re eating and drinking those kinds of things!).

  A special note about Splenda – “The Zero Calorie Sweetener” It’s about 2 calories per little yellow packet. And they can add up very quickly if you’re putting Splenda into everything.

As it gets hotter, it's tempting to drink more sweet beverages. We hope you have an opportunity to try Solixir, the functional, herb-containing beverage we profiled on our radio show last week.

Here are a few other ways to spice your water up a bit without adding unnecessary sugar or high-fructose corn syrup.

1. Mix a little bit of Hint Essence Water in with regular or mineral water. Just a little changes the flavor enough to remove the monotony.

2. Throw some mint leaves and cucumber slices in your water. I've learned, the longer it sits, the better it gets!

3. Freeze fruit juice in your ice cube trays and drop in your drink.

4. Freeze whole fruit or fruit chunks and do the same thing.

5. Try Sweet Leaf flavored stevia drops. inCYST intern Sarah Jones' favorite cooler is a few drops of vanilla creme in mineral water for an instant sugar-free cream soda.