If you're trying to conceive, you likely know that it's important to be getting enough folate in your diet in order to prevent neural tube defects.
Even if you're NOT trying to get pregnant, folate is important for women with PCOS.
Homocysteine is a compound found in the blood, which, in elevated amounts, indicates increased cardiovascular risk and inflammation. It tends to be elevated in women with PCOS.
Fifty patients with PCOS, were divided into two groups receiving two different treatments. The first group received 1700 mg of metformin per day, along with 400 mug folate. The second group received metformin without folate.
Homocysteine levels were significantly increased in both groups, but to a lesser degree when they also supplemented with folate.
I was heartened to see this study, since so much research on PCOS focuses on the part of PCOS we can SEE (i.e., weight), and seems to ignore that biochemistry can be altered regardless of weight. In fact, another study I ran across while looking for a blog topic this morning, focused on the fact that metformin improved biochemistry even without diet or exercise modifications. Yes, you can make a study say anything you wish if you correctly design it, but it is not fair to women with PCOS to do that and falsely lead them to believe that medication is the only answer. And, you've got to understand that even if your weight is normal with PCOS, you still have to pay attention to what is happening metabolically.
You've got to care about what's under the hood, not just how pretty the paint job is.
Palomba S, Falbo A, Giallauria F, Russo T, Tolino A, Zullo F, Colao A, Orio F. Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome. Diabetes Care. 2009 Nov 23. [Epub ahead of print]
Oppelt PG, Mueller A, Janetsch K, Kronawitter D, Reissmann C, Dittrich R, Beckmann MW, Cupisti S. The Effect of Metformin Treatment for 2 Years without Caloric Restriction on Endocrine and Metabolic Parameters in Women with Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2009 Dec 8. [Epub ahead of print]