Yesterday I reported on research suggesting that myoinositol was effective in creating more viable eggs than d-chiro-inositol, but qualified that the study was performed on women with PCOS whose insulin function was normal. Guess what…myoinositol does that too!
Again, this experiment was conducted in conjunction with the administration of folate, so realistically re-creating this in your own home laboratory may require both.
Forty-two women with PCOS were treated in a double-blind trial with myoinositol plus folic acid or folic acid alone by itself. The myoinositol group, at the end of the study, experienced lower serum total testosterone, serum free testosterone, plasma triglycerides, systolic blood pressure, diastolic blood pressure, and area under the plasma insulin curve after oral administration of glucose. And insulin sensitivity increased. 16 out of 23 women given myoinositol group ovulated, compared to 4 out of 19 in placebo group.
When this information is combined with the information I wrote about yesterday, what it seems to say is that myoinositol creates an environment where a pregnancy is not only more likely to occur and but also to sustain itself. One of the frustrations I have expressed here before is that while metormin helps to increase ovulation rate, it doesn't transfer to babies at the end of the path. I don't have to tell you how frustrating it is to know you've got half the system up and running and nothing you try seems to make the other half cooperate.
Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):105-10.
Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol. 2008 Mar;24(3):139-44.